Synthesis and characterization of a penicillin-poly(L-lysine) which is recognized by human IgE anti-penicillin antibodies

Abstract

Conjugates of poly(L-lysine) containing a penicillin or a penicilloyl residue were prepared and characterized by 1H NMR and by size-exclusion HPLC. These conjugates and conjugates with human serum albumin were used in radioallergosorbent tests (RAST) for the determination of allergy toward penicillins.