The Effect of Oxygen Breathing at Atmospheric Pressure on the Metabolism of Glycerol and Ethanol in Cats.

Abstract

Abstract It was found that breathing of oxygen may depress the elimination rate of glycerol in chloralose anesthetized cats.but the depressive effect was highly dependent on the simultaneous metabolism of ethanol.When glycerol and ethanol were infused together, the addition of glycinc increased the elimination rate of glycerol.This increase was inhibited by oxygen breathing.A similar although less pronounced change was seen in the metabolism of ethanol.The results suggest that the effect of oxygen breathing may be explained by inhibition of dehydrogenases responsible for the oxidation of ethanol and by inhibition of the production of adenosine‐5‐triphosphate.