Micronuclei as a biological endpoint for genotoxicity: A minireview

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

Andrew P. Feinberg, Bert Vogelstein · Nature · 1983 · 2.4K citations

Medicine, Genetics, Molecular Genetics +13

Fragile sites are targets of diverse mutagens and carcinogens.

Juan J. Yunis, A. Lee Soreng, A E Bowe · PubMed · 1987 · 259 citations

Pharmacy, Genetics, Molecular Genetics +9

Hypothesis: some mutagens directly alter specific chromosomal proteins (DNA topoisomerase II and peripheral proteins) to produce chromosome stickiness, which causes chromosome aberrations

Mary Esther Gaulden · Mutagenesis · 1987 · 189 citations

Life Sciences, Genetics, Radiation Oncology +17

Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.

Daniel D. Von Hoff, J. McGill, B Forseth et al. · Proceedings of the National Academy of Sciences · 1992 · 188 citations

Medicine, Genetics, Oncology +16

Complex composition and co‐amplification of <i>SAS</i> and <i>MDM2</i> in ring and giant rod marker chromosomes in well‐differentiated liposarcoma

Florence Pédeutour, Ron F. Suijkerbuijk, Anne Forus et al. · Genes Chromosomes and Cancer · 1994 · 180 citations

Life Sciences, Genetics, Oncology +13