Publication | Closed Access
Enantioselective Total Synthesis of the Cyclophilin-Binding Immunosuppressive Agent Sanglifehrin A This work was financially supported by Eli Lilly and Company and a Robert Mayer Graduate Fellowship (to M.D.). We thank Prof. K. C. Nicolaou for providing authentic spectra of 1.
42
Citations
0
References
2001
Year
Bioorganic ChemistryMolecular BiologySubsequent LinkupChemical BiologySynthetic ImmunologyMedicinal ChemistryAuthentic SpectraDiversity Oriented SynthesisStereoselective SynthesisEastern SectorMacromolecular AssembliesImmunosuppressive AgentBiochemistryDiversity-oriented SynthesisBioconjugationMechanism Of ActionEnantioselective Total SynthesisNatural Product SynthesisPharmacologyEnantioselective SynthesisBiomolecular EngineeringNatural SciencesEli LillyMedicineDrug Discovery
Crafting of the building blocks 1–3 allows the convergent conjoining of 2–3 in advance of macrolactonization. The subsequent linkup of the eastern sector with 1 by Stille coupling enabled the convenient stereocontrolled assembly of the immunosuppressive agent (−)-sanglifehrin A (Boc=tert-butoxycarbonyl).