Erythrocytosis Associated with Haemoglobin Malmö, Accompanied by Pulmonary Changes, Occurring in the Same Family

Abstract

Erythrocytosis was found in 6 members of one family and was associated with the presence of a new abnormal haemoglobin, Hb Malmö β 97 (FG 4) His → Gln showing increased affinity for oxygen. Radiological pulmonary changes, possibly precancerous, also occurred in several members of the family. The pulmonary changes and Hb Malmö are thought to be caused by separate genes, and the mode of inheritance of both is considered autosomal dominant.