Concepedia

Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-Bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine

Natalia A. Loktionova, Meng Xu‐Welliver, Tina M. Crone, Sreenivas Kanugula, Anthony E. Pegg

Biochemical Pharmacology · 1999 · 31 citations · 31 references

DOI

Concepts

References

31

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

M. Eileen Dolan, Robert C. Moschel, Anthony E. Pegg · Proceedings of the National Academy of Sciences · 1990 · 461 citations

, , +9

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

Leonard C. Erickson, Laurent Guy, Nancy A. Sharkey et al. · Nature · 1980 · 312 citations

, , +16

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.

H. S. Friedman, Demetrius M. Kokkinakis, James M. Pluda et al. · Journal of Clinical Oncology · 1998 · 217 citations · Full text

, , +16

O6-benzylguanine and its role in chemotherapy.

M. Eileen Dolan, Anthony E. Pegg · PubMed · 1997 · 216 citations

, , +16

DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas.

Leonard C. Erickson, Matthews O. Bradley, Jonathan M. Ducore et al. · Proceedings of the National Academy of Sciences · 1980 · 147 citations · Full text

, , +16