In vitro toxicity of MTA Compared with other Primary Teeth Pulpotomy Agents

Abstract

OBJECTIVE: The main goal of this work is to compare the In vitro toxicity of MTA with other primary teeth pulpotomy agents. STUDY DESIGN: The In vitro toxicity of MTA, calcium hydroxide, ferric sulphate solution, diluted formocresol and Buckley's formocresol were tested using MTT and Neutral Red Uptake cell viability assays. The results for MTA were compared to those obtained for the other substances using ANOVA and Tukey statistical tests (p < 0.05). RESULTS: MTA had the lower in vitro toxicity and Buckley's formocresol, the higher, with statically significant difference. CONCLUSION: Among the primary teeth pulpotomy agents tested, MTA showed the lower In vitro toxicity, standing as the most promising substitute to formocresol.