Concepedia

Cannabinoid Receptor 2 Expression in Human Proximal Tubule Cells is Regulated by Albumin Independent of ERK1/2 Signaling

Kayte A. Jenkin, Andrew J. McAinch, Jessica F. Briffa, Yuan Zhang, Darren J. Kelly, Carol A. Pollock, Philip Poronnik, Deanne H. Hryciw

Cellular Physiology and Biochemistry · 2013 · 29 citations · 17 references

DOIFull text

Open access

Abstract

We have demonstrated that internalization of albumin is required to reduce CB2 mRNA and protein expression in proximal tubules in vitro. Consequently, altered expression of CB2 in both the podocytes and tubules may contribute to the albuminuria observed in T2DM.

References

17

Cannabinoid receptors regulate Ca2+ signals and insulin secretion in pancreatic β-cell

Pablo Juan-Picó, Esther Fuentes, Francisco J. Bermúdez‐Silva et al. · Cell Calcium · 2005 · 256 citations

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Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy

Partha Mukhopadhyay, Mohanraj Rajesh, Hao Pan et al. · Free Radical Biology and Medicine · 2009 · 217 citations · Full text

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CANnabinoid Receptor Type 2 Activation Induces a Microglial Anti-Inflammatory Phenotype and Reduces Migration via MKP Induction and ERK Dephosphorylation

E. Alfonso Romero‐Sandoval, Ryan J. Horvath, Russell P. Landry et al. · Molecular Pain · 2009 · 156 citations · Full text

CB<sub>1</sub> cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model

Partha Mukhopadhyay, Hao Pan, Mohanraj Rajesh et al. · British Journal of Pharmacology · 2010 · 150 citations · Full text

Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy

Federica Barutta, Alessandro Corbelli, Raffaella Mastrocola et al. · Diabetes · 2010 · 145 citations · Full text