Concepedia

Pseudomonas aeruginosa Virulence Expression Is Directly Activated by Morphine and Is Capable of Causing Lethal Gut-Derived Sepsis in Mice During Chronic Morphine Administration

Trissa Babrowski, Christopher Holbrook, Jonathan Moss, Lawrence J. Gottlieb, Vesta Valuckaite, Alexander Zaborin, Valeriy Poroyko, Donald C. Liu, Olga Zaborina, John C. Alverdy

Annals of Surgery · 2011 · 123 citations · 35 references

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Open access

Abstract

Morphine administration shifts intestinal P. aeruginosa to express a virulent phenotype and may play a role in its ability to causes lethal gut-derived sepsis in a susceptible host.

References

35

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Malin Johansson, Mia Phillipson, Joel Petersson et al. · Proceedings of the National Academy of Sciences · 2008 · 2.1K citations · Full text

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The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions

Malin Johansson, Jessica M. Holmén Larsson, Gunnar C. Hansson · Proceedings of the National Academy of Sciences · 2010 · 1.4K citations

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

Kirk Bergstrom, Vanessa Kissoon‐Singh, Deanna L. Gibson et al. · PLoS Pathogens · 2010 · 613 citations · Full text

Construction of improved Escherichia-Pseudomonas shuttle vectors derived from pUC18/19 and sequence of the region required for their replication in Pseudomonas aeruginosa

S E West, Herbert P. Schweizer, C. Dall et al. · Gene · 1994 · 570 citations

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Importance and regulation of the colonic mucus barrier in a mouse model of colitis

J Petersson, Olof Schreiber, Gunnar C. Hansson et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 2010 · 370 citations · Full text