Journal of the American Chemical Society · 2007 · 612 citations · 19 references
PharmacyPharmaceuticsPharmacologyChemotherapyDrug DeliveryNanomaterialsCancer Drug DeliveryCancer NanomedicineDrug EncapsulationNanocarriers For TherapeuticsNanomedicineNanotubesCancer NanotherapyCarbon Nanotube Drug DeliveryChemotherapy DeliveryDrug Delivery NanocarriersNanocarrier-based ProdrugsNanoparticle-delivered ProdrugsProdrug-drug ConjugatesSingle-walled Carbon Nanotubes
Amine-functionalized soluble single-walled carbon nanotubes (SWNTs) were derivatized with cisplatin prodrug conjugates as a delivery system by which to internalize multiple prodrug centers. The platinum(IV) complex, c, c, t -[Pt(NH 3 ) 2 Cl 2 (OEt)(O 2 CCH 2 CH 2 CO 2 H)], was tethered to the surface of the carbon nanotubes through peptide linkages formed by the reaction of the SWNT-tethered amines with the carboxylate moiety. The SWNTs were taken into testicular cancer cells by endocytosis, where the drop in pH facilitates reductive release of the platinum(II) core complex, which then readily diffuses throughout the cell, as determined by platinum atomic absorption spectroscopy. The entrapment of the SWNTs within the endosomes was confirmed by fluorescence microscopy of SWNTs containing both tethered fluorescein and platinum units. The cytotoxicity of the free platinum(IV) complex increases by >100-fold when the complex is attached to the surface of the functionalized SWNTs.
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Nadine Wong Shi Kam, Michael O’Connell, Jeffrey Wisdom et al. · Proceedings of the National Academy of Sciences · 2005 · 2.3K citations · Full text
In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
Weibo Cai, Nozomi Nakayama, Xiaoming Sun et al. · Nature Nanotechnology · 2006 · 1.4K citations