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Thieme Chemistry Journal Awardees - Where Are They Now? Aldol Synthesis by anti-Markovnikov Hydration of Propargyloxy Substrates: Feasibility, Stereospecifity, and Reiterative Alkynylation-Hydration
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2009
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Aldol DerivativesBioorganic ChemistryEngineeringBiochemistryNatural SciencesAnti-markovnikov HydrationOrganic ChemistryCatalysisStereoselective SynthesisPropargyloxy SubstratesReiterative Alkynylation-hydrationAlkyne HydrationAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
Aldol derivatives have been synthesized by redox-neutral catalytic anti-Markovnikov hydration of propargyloxy substrates. A reiterative sequence of aldehyde alkynylation and alkyne hydration leads to 1,3-polyol derivatives.