In vitro radiosensitivity of human leukemia cell lines.

R.R. Weichselbaum, Joel S. Greenberger, Adriana Prato Schmidt, Abraham Karpas, William C. Moloney, J B Little

Radiology · 1981 · 56 citations · 0 references

Concepts

Abstract

The in vitro radiobiologic survival values (n, D0) of four tumor lines derived from human hematopoietic tumors were studied. These cell lines were HL50 (n = 1.3, D0 = 117 rad[1.17 Gy]), promyelocytic leukemia; K562 (n = 1.4, D0 = 165 rad[1.65 Gy]), erythroleukemia; 45 (n = 1.1, D0 = 147 rad[1.47 Gy]), acute lymphocyte leukemia; and 176 (n = 4.0, D0 = 76 rad[0.76 Gy]), acute monomyelogenous leukemia. More cell lines must be examined before the exact relationship between in vitro radiosensitivity and clinical radiocurability is firmly established.