Fructose- 1,6-Bisphosphate Supports Cerebral Energy Metabolism in Pigs after Ischemic Brain Injury Caused by Experimental Particle Embolization

Abstract

The administration of FDP before and immediately after HCA combined with embolic brain ischemic injury was associated with significantly lower brain lactate/pyruvate ratio and significantly higher levels of brain pyruvate, as well as lower lactate levels 8 hours after HCA. FDP seems to protect the brain by supporting energy metabolism. The neurological outcome was not improved, most likely resulting from the irreversible nature of the microsphere occlusion.