A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10

Christian Bogdan, J Paik, Yoram Vodovotz et al. · Journal of Biological Chemistry · 1992 · 513 citations · Full text

Life Sciences, Cell Biology, Immunology +16

Macrophage deactivating factor and transforming growth factors- <i>beta</i>  1 - <i>beta</i>  2 and - <i>beta</i>  3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

Aihao Ding, Carl Nathan, Jeannette L. Graycar et al. · The Journal of Immunology · 1990 · 500 citations

Life Sciences, Cell Biology, Immunology +14

A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.

Nanjoo Suh, Yongping Wang, Tadashi Honda et al. · PubMed · 1999 · 283 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Synthetic Oleanane and Ursane Triterpenoids with Modified Rings A and C:  A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages

Tadashi Honda, BarbieAnn V. Rounds, Lothar Bore et al. · Journal of Medicinal Chemistry · 2000 · 236 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages

Tadashi Honda, BarbieAnn V. Rounds, Gordon W. Gribble et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 204 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17