INHIBITION OF THYROID FUNCTION IN BEAGLE PUPPIES BY PROPYLTHIOURACIL WITHOUT DISTURBANCE OF GROWTH OR HEALTH

Abstract

INTRODUCTION ALTHOUGH dogs have been used extensively in thyroidectomy experiments, these animals have been mentioned seldom in publications on antithyroid compounds. The cabbage factor and cyanide type of antithyroids have not been tried in dogs at all, as far as we know. A few papers report dogs experiments with antithyroid compounds of the sulfanilamide and thiourea types. Danowski et al. (1945) administered large doses of thiouracil or thiourea to 3 adult dogs for 28 to 40 weeks without obtaining any syndrome comparable to human myxedema. Mackenzie and Mackenzie (1943) snowed that sulfaguanidine altered the mopphology of the thyroid glands in two puppies in the same way as in rats; the puppies were about 4 months old, and were sacrificed after 2 and 3 weeks of drug administration.