Multi-nuclear platinum complexes as anti-cancer drugs

Chemical and biological properties of a new series of cis-diammineplatinum(II) antitumor agents containing three nitrogen donors: cis-[Pt(NH3)2(N-donor) Cl]+

L. Steven Hollis, Alan R. Amundsen, Eric Stern · Journal of Medicinal Chemistry · 1989 · 235 citations

Pharmacotherapy, New Series, Metronomic Chemotherapy +20

DNA Modifications by a Novel Bifunctional Trinuclear Platinum Phase I Anticancer Agent

Viktor Brabec, Jana Kašpárková, Oldøich Vrána et al. · Biochemistry · 1999 · 204 citations

In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473

J Holford, Barry A. Murrer, Michael J. Abrams · British Journal of Cancer · 1998 · 198 citations · Full text

Health Sciences, Platinum Complex Amd473, Vitro Circumvention +6

A comparison of chemical reactivity, cytotoxicity, interstrand crosslinking and DNA sequence specificity of bis(platinum) complexes containing monodentate or bidentate coordination spheres with their monomeric analogs

Nicholas P. Farrell, Yun Qu, Lan Feng et al. · Biochemistry · 1990 · 170 citations

Cytotoxicity and antitumor activity of bis(platinum) complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1,2-diaminocyclohexane complexes

Nicholas P. Farrell, Yun Qu, Miles P. Hacker · Journal of Medicinal Chemistry · 1990 · 161 citations