The determination of hydrophile‐lipophile balance by gas‐liquid chromatography

Abstract

Abstract Measurement of the relative retention time of a pair of liquids, one polar and one nonpolar, permits determination of the polarity of the liquid Chromatographic substrate. It is shown that this polarity is a measure of the hydrophile‐lipophile balance (HLB) when the substrate is a surface‐active agent. The effects of structure, additivity in mixtures, and free polyol are discussed. A GLC apparatus, designed, to permit the rapid determination of HLB by this technique, is described.