Sequential mass spectrometry and MSn analyses of combinatorial libraries by using automated matrix-assisted laser desorption/ionization Fourier transform mass spectrometry

Abstract

This note demonstrates that accurate mass and MS/MS data can be rapidly and easily obtained using an automated matrix-assisted laser desorption/ionization Fourier transform MS procedure for multiple samples. Multiple ionization techniques were used simultaneously in order to introduce sample and mass reference ions into the Fourier transform ion cyclotron resonance cell. In this way 20 samples from a combinatorial library were analyzed automatically in one hour, with RMS errors of less than 5 ppm for the masses of both parent and fragment ions. © 1998 John Wiley & Sons, Ltd.