Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

Abstract

Against nuclear export! Immunofluorescence assays indicate that anguinomycin C is a potent inhibitor of protein export from the nucleus. Key features in the total synthesis of this antitumor natural product include a Cr-catalyzed enantioselective hetero-Diels–Alder reaction, a Negishi reaction with stereoinversion, and application of the DIOZ auxiliary.