Journal of Pharmacy and Pharmacology · 1973 · 18 citations · 1 references
PharmacyPharmaceutical AnalysisPharmacologyAnalytical ChemistryChromatographic AnalysisPsychopharmacologyChromatographic Analysis Of PharmaceuticalsChromatographyClinical AnalysisGas ChromatographyInstrumental AnalysisLiquid ChromatographyBlood Drug AnalysisBlood Drug MonitoringBlood Drug TestingChromatographic InstrumentationElectron Capture Detection
Abstract The blood levels attained at therapeutic oral doses of ICI 58 834 hydrochloride, a novel psychotropic agent, are adequately assayed by gas-liquid chromatography. The free base is extracted into benzene and converted to its heptafluorobutyrate derivative. The derivative is chromatographed on a column of 1% XE60 on Gas-Chrom Q and detected by electron capture. Recovery from blood is 80–90% and the minimum detectable level is about 20 ng compound ml−1 whole blood.
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