Antituberculous Activity of Substituted Thioureas

Abstract

1. Over 350 thioureas have been prepared in our laboratories and tested for antitubercular activity. 2. A number of disubstituted thioureas have demonstrated considerable protective and therapeutic activities in tuberculous mice and guinea pigs. 3. Little correlation existed between the in vitro and in vivo tuberculostatic action. 4. Many compounds possessed strong antifungal as well as antimycobacterial properties.