Clinical and Serologic Studies of an Outbreak of Rubella in a Vaccinated Population

Abstract

HUMAN studies of several vaccines prepared from attenuated rubella virus have indicated their immunogenicity, noncommunicability and relative lack of untoward effects in children. Because a decrease or total loss of immunizing capacity has been noted with increase in the number of tissue-culture transfers carried out during attenuation,1,2 all the viruses now employed as vaccines have been carried through only a limited number of passages. Despite this, these preparations are not as antigenically active as the parent strains. Complement-fixing (CF) antibody rarely develops after their use, and hemagglutinin-inhibition (HI) and neutralizing-antibody titers are much lower than those that result from naturally . . .