Production and characterization of a recombinant anti-MUC1 scFv reactive with human carcinomas

Continuous cultures of fused cells secreting antibody of predefined specificity

Georges Köhler, César Milstein · Nature · 1975 · 17.2K citations

Pharmacy, Cell Biology, Immunology +11

Phage antibodies: filamentous phage displaying antibody variable domains

John McCafferty, Andrew D. Griffiths, Greg Winter et al. · Nature · 1990 · 2.4K citations

Pharmacy, Immunology, Molecular Biology +16

Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms.

Takashi Yokota, Diane E. Milenic, Marc Whitlow et al. · PubMed · 1992 · 826 citations

Pharmacy, Oncology, Pharmacokinetics +17

A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats.

Sandra Gendler, Joyce Taylor‐Papadimitriou, Trevor Duhig et al. · Journal of Biological Chemistry · 1988 · 574 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells.

Keith R. Jerome, Donna L. Barnd, Katharine M. Bendt et al. · PubMed · 1991 · 353 citations

Life Sciences, Immunology, Oncology +17