Dual Targeting of Endothelial Cells and Pericytes in Antivascular Therapy for Ovarian Carcinoma

Abstract

Strategies targeting both endothelial cells and pericytes are highly effective for in vivo treatment of ovarian carcinoma. This antiangiogenic effect may be partially due to decreased pericyte coverage, thus increasing the sensitivity of tumor vasculature to therapy. These encouraging data support the development of clinical trials based on this strategy.