The Application of<i>N</i>-Substituted Trichloroacetamides as<i>in situ</i>Isocyanate Generating Reagents for the Synthesis of Acylureas and Sulfonylureas - Concepedia

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The Application of<i>N</i>-Substituted Trichloroacetamides as<i>in situ</i>Isocyanate Generating Reagents for the Synthesis of Acylureas and Sulfonylureas

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References

1987

Year

I. A. Atanassova, J. S. Petrov, N. M. Mollov

Derivative (Chemistry)Sulfonamides 2Dimethylsulfoxide SolutionPowdered Sodium HydroxideOrganic ChemistryChemistryHeterocycle ChemistryReagentPharmacologyChemical DerivativeSynthetic ChemistryNatural Product Synthesis

Abstract

In dimethylsulfoxide solution in the presence of excess of powdered sodium hydroxide, N-subsituted trichloroacetamides 1 are used as in situ isocyanate generating reagents which can react with carboxamides or sulfonamides 2 to afford acylureas or sulfonylureas 3.