Concepedia

Activation of the inducible nitric oxide synthase pathway contributes to inflammation-induced osteoporosis by suppressing bone formation and causing osteoblast apoptosis

Kenneth J. Armour, Katharine E. Armour, Rob vanʼt Hof, David M. Reid, Xiaoqing Wei, Foo Y. Liew, Stuart H. Ralston

Arthritis & Rheumatism · 2001 · 105 citations · 13 references

DOI

Abstract

Inducible NOS-mediated osteoblast apoptosis and depressed bone formation play important roles in the pathogenesis of IMO.

References

13

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Young‐Yun Kong, Ulrich Feige, Iidiko Sarosi et al. · Nature · 1999 · 1.9K citations

, , +14

Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.

Robert S. Weinstein, R L Jilka, A. M. Parfitt et al. · Journal of Clinical Investigation · 1998 · 1.7K citations · Full text

, , +18

Altered immune responses in mice lacking inducible nitric oxide synthase

Xiaoqing Wei, Ian G. Charles, Austin Smith et al. · Nature · 1995 · 1.3K citations

, , +11

Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.

Hiroshi Sakurai, Hitoshi Kohsaka, Meng‐Fan Liu et al. · Journal of Clinical Investigation · 1995 · 391 citations · Full text

, , +19

Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism

Michael J. Rogers, Kattya M. Chilton, Fraser P. Coxon et al. · Journal of Bone and Mineral Research · 1996 · 196 citations

, , +17