Concepedia

Homocysteine and copper interact to promote type 5 phosphodiesterase expression in rabbit cavernosal smooth muscle cells

Matthew Hotston, Jamie Y. Jeremy, Jonathon Bloor, Nick S. Greaves, Raj Persad, Gianni D. Angelini, Nilima Shukla

Asian Journal of Andrology · 2008 · 22 citations · 28 references

DOIFull text

Open access

Abstract

This represents a novel pathogenic mechanism underlying ED, and indicates that the therapeutic actions of prolonged sildenafil use are mediated in part through inhibition of this pathway.

References

28

5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide Production in Human Vessels

Charalambos Antoniades, Cheerag Shirodaria, N Warrick et al. · Circulation · 2006 · 353 citations

Effects of sildenafil, a type‐5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum <i>in vitro</i>

Jamie Y. Jeremy, Stephen A. Ballard, A.M. Naylor et al. · British Journal of Urology · 1997 · 250 citations

Plasma Copper and Antioxidant Status in Wilson's Disease

Hiromi Ogihara, Tohru Ogihara, Masayuki Miki et al. · Pediatric Research · 1995 · 117 citations · Full text

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Sildenafil inhibits the formation of superoxide and the expression of gp47 <sup>phox</sup> NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells

Anthony Koupparis, Jamie Y. Jeremy, Saima Muzaffar et al. · British Journal of Urology · 2005 · 115 citations

Investigation of the inhibitory effects of homocysteine and copper on nitric oxide‐mediated relaxation of rat isolated aorta

Alison M Emsley, Jamie Y. Jeremy, Guiomar Nascimento Gomes et al. · British Journal of Pharmacology · 1999 · 91 citations · Full text