A New Macrocyclic Trichothecene, 12,13-Deoxyroridin E, Produced by the Marine-Derived Fungus <i>Myrothecium </i><i>r</i><i>oridum</i> Collected in Palau

Abstract

A new macrocyclic trichothecene, 12,13-deoxyroridin E (1), and three known compounds, roridin E (2), verrucarin A (3), and verrucarin J (4), were obtained as cytotoxic components from the marine-derived fungus Myrothecium roridum, isolated in Palau. 12,13-Deoxyroridin E is the second example of a macrocyclic trichothecene possessing a double bond at C-12-C-13 and was about 80-fold less cytotoxic than roridin E, the epoxide variant.