Development of Brugia pahangi infections and lymphatic lesions in male offspring of female jirds with homologous infections

Abstract

The development of Brugia pahangi infections and associated gross lymphatic lesions were compared in male offspring from B. pahangi-infected and uninfected female jirds. The numbers of adult worms recovered did not differ between groups but a greater number of offspring of infected females (92%) developed circulating microfilaraemias than did individuals from uninfected females (50%). Intralymphatic granulomatous thrombi, lymphatic dilatations and lymphatic lesion scores were significantly reduced in offspring from infected mothers.