Effects of Pre- and Postischemic Administration of Thiopental on Transmitter Amino Acid Release and Histologic Outcome in Gerbils

Abstract

Thiopental helps protect the brain from ischemia, although treatment with this agent after ischemia requires a larger dose than that before ischemia. The effect of preischemic treatment may be related to the suppression of the excitatory amino acid release and the direct-current potential shift.