Penetration of Lincomycin, Penicillin, and Tetracycline into Serum and Bone

Abstract

SummaryThe penetration of lincomycin into serum, femur, and mandible was compared with penicillin G and tetracycline following intramuscular injection. The concentrations were assayed by the serial tube dilution method using S. aureus. Lincomycin produced higher concentrations than penicillin in serum and bone. Although tetracycline gave higher serum levels than the other two antibiotics, a sufficient quantity could not be extracted from the bone by the method used to permit detection by the test organism. However, its presence was confirmed by the bacteriostatic effect of the bone powder upon inoculated broth cultures.