Polymer Scaffolds for Biomaterials Applications

TLDR

Biomaterials are widely used in medical, personal care, and food applications, and tissue engineering research focuses on designing scaffolds with appropriate chemical, physical, and mechanical properties, integrating cells or biomolecules, and delivering growth factors to promote tissue regeneration. This Perspective focuses on polymer scaffolds designed for delivering cells and biomolecules in regenerative medicine, highlighting their role in tissue engineering. The article examines challenges and solutions in designing polymeric biomaterial scaffolds with suitable three‑dimensional structures.

Abstract

Biomaterials have been used extensively in medical, personal care, and food applications, with many similar polymers being used across disciplines. This Perspective will emphasize polymers used in medicine and specifically those designed as scaffolds for use in tissue engineering and regenerative medicine. The areas of active research in tissue engineering include: biomaterials design—incorporation of the appropriate chemical, physical, and mechanical/structural properties to guide cell and tissue organization; cell/scaffold integration—inclusion into the biomaterial scaffold of either cells for transplantation or biomolecules to attract cells, including stem cells, from the host to promote integration with the tissue after implantation; and biomolecule delivery—inclusion of growth factors and/or small molecules or peptides that promote cell survival and tissue regeneration. While a significant and growing area of regenerative medicine involves the stimulation of endogenous stem cells, this Perspective will emphasize polymer scaffolds used for delivery of cells and biomolecules. The challenges and solutions pursued in designing polymeric biomaterial scaffolds with the appropriate 3-dimensional structure will be explored.