IgE-Independent Mast Cell Activation Augments Contractility of Nonpregnant and Pregnant Guinea Pig Myometrium

Abstract

In summary, mast cells increase uterine contractility through multiple mediators, and uterine responses to these mediators are dependent on gestational age. We postulate that the simultaneous release of these mast cell/eosinophil mediators in the uterus could be a stimulus to trigger and/or maintain myometrial contractions during preterm and term labor.