Science · 1974 · 422 citations · 16 references
Central ActionsPituitary GlandRegional DistributionNeuroendocrine MechanismHypothalamic PeptideHealth SciencesEndocrine MechanismHypothalamusNeuropharmacologySpecific RadioimmnunoassayNervous SystemEndocrinologyNeurophysiologyNeuroanatomyPhysiologyNeuroscienceCentral Nervous SystemThyroid HormoneMedicineTotal Brain Content
A sensitive and specific radioimmnunoassay has been used to measure the distribution of thyrotropin-releasing hormone (TRH) in rat brain. All areas of brain tested, except cerebellum, contained readily measurable amounts of TRH. The hypothalamus contained only 31.2 percent of the total brain content of TRH. These results support recent suggestions of central actions for TRH in addition to its hypophysiotropic functions.
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L Wickstrom, K Pettersson · PubMed · 1964 · 1.2K citations
EFFECTS OF THYROTROPIN-RELEASING HORMONE IN DEPRESSION*1
Arthur J. Prange · The Lancet · 1972 · 559 citations · Full text