Journal of the American Medical Association · 1946 · 87 citations · 12 references
MedicineOncologyPathologyCytopathologyHistologyHistopathologyCervical BiopsyCervical CytologyCervical HistopathologyCervical LesionsCervical PathologyCervicovaginal CytologyCervical Carcinoma In SituClinical Cancer DiagnosisInvasive Cervical CarcinomaPreinvasive Neoplasia
The recognition of carcinoma of the cervix in a truly early stage is one of the recent advances in the effort to control the disease. These preinvasive neo-plastic lesions have been more frequently detected as acceptance of their nature has become more general among surgeons and pathologists and as material for microscopic study, both biopsies and whole cervices, has become more abundant. In brief, the lesions are being found because a search is being made for them. Ample and concise descriptions of the histopathology are available,<sup>1</sup>and microscopic differentiation from noncancerous squamous metaplasia has been emphasized.<sup>2</sup>As yet, however, most of the studies are based on relatively few cases, and our knowledge is correspondingly incomplete. Evidence of the potentialities of the lesions has been furnished by the observation that clinical cancer has followed untreated or inadequately treated carcinoma in situ.<sup>3</sup>On the other hand, cancer has failed
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