Enantioselective Synthesis of (−)-Sclerophytin A by a Stereoconvergent Epoxide Hydrolysis

Abstract

The cytotoxic natural product (-)-sclerophytin A was constructed in 13 steps from geranial. Highlights from the synthesis are a stereoselective Oshima-Utimoto reaction, a Shibata-Baba indium-promoted radical cyclization, and a novel stereoconvergent epoxide hydrolysis.