Journal of Physics Conference Series · 2009 · 38 citations · 0 references
PharmacyMaterials SciencePharmaceuticsDrug DeliveryNanomaterialsPolymer ChemistryDrug FormulationNanoparticle CharacterizationNanoparticle FormulationsNanoparticle SynthesisPolymeric NanomaterialsPolymeric NanoparticlesDrug - Polymer InteractionsDynamic Light ScatteringGlass TransitionGlass Transition TemperatureNanoparticlesParticle-size DistributionPolymeric Nanoparticle CharacterizationPolymeric Nanoparticle Synthesis
Polymeric drug nanoparticles were prepared by emulsion solvent evaporation method. In this study, prepared the polymeric drug nanoparticles consist of ketoprofen and Eudragit E 100. The morphology structure was investigated by scanning electron microscopy (SEM). The interactions between the drug and polymer were investigated by Fourier transform infrared spectroscopy (FTIR). The size distribution was measured by means of Dynamic Light Scattering. The nanoparticles have an average size of about 150 nm. The incorporation ability of drugs in the polymeric nanoparticles depended on the integration between polymer and drug as well as the glass transition temperature of the polymer.