General Method for Synthesis of Bipyridines: Palladium Catalyzed Cross-coupling Reaction of Trimethylstannyl-pyridines with Bromopyridines

Abstract

Trimethylstannylpyridines 1 were treated with bromopyridines 2 in the presence of catalytic amount of tetrakis(triphenylphosphine)palladium to give the corresponding bipyridines 3 in moderate to good yields. Nicotelline (6) was similarly synthesized from 2, 4-bis(trimethylstannyl)pyridine (5) and 3-bromo-pyridine (2b).