Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(1716)65Dn and mouseChromosome 12

The DNA sequence of human chromosome 21

Masahira Hattori, Asao Fujiyama, Todd D. Taylor et al. · Nature · 2000 · 1.5K citations · Full text

Chromatin, Developmental Biology, Cytogenetics +14

A mouse model for Down syndrome exhibits learning and behaviour deficits

Roger H. Reeves, Nicholas G. Irving, Timothy H. Moran et al. · Nature Genetics · 1995 · 906 citations

Down Syndrome, Behavioral Sciences, Neuropsychology +14

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

David M. Holtzman, Daniela Santucci, Joshua F. Kilbridge et al. · Proceedings of the National Academy of Sciences · 1996 · 446 citations · Full text

Genetics, Neurochemical Biomarkers, Developmental Abnormalities +19

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

Haruhiko Sago, Elaine J. Carlson, Desmond Smith et al. · Proceedings of the National Academy of Sciences · 1998 · 377 citations · Full text

Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome

Pavel V. Belichenko, Eliezer Masliah, Alexander M. Kleschevnikov et al. · The Journal of Comparative Neurology · 2004 · 300 citations