Inhibitory Effects of Acylated Acyclic Sesquiterpene Oligoglycosides from the Pericarps of Sapindus rarak on Tumor Necrosis Factor-.ALPHA.-Induced Cytotoxicity

Abstract

Four new acylated acyclic sesquiterpene oligoglycosides (1-4) were isolated from the pericarps of Sapindus rarak DC. together with four known acyclic sesquiterpene oligoglycosides, mukuroziosides Ia (5), Ib (6), IIa (7), and IIb (8). Their structures were elucidated on the basis of chemical and physicochemical evidence. These newly isolated compounds (1-4) were found to show inhibitory effects on tumor necrosis factor-alpha-induced cytotoxicity in L929 cells at concentrations of 30-100 microM.