Proceedings of the National Academy of Sciences · 1974 · 80 citations · 26 references
Life SciencesBiochemistryCell BiologyCell ProliferationCell SignalingSignal TransductionAnimal Cell CultureCell Proliferation ControlCyclic Nucleotide SignalingGrowth Factor SignalingAdenylate Cyclase RegulationAdenylate Cyclase SignalingAdenylyl Cyclase RegulationAdenylyl Cyclase SignalingCyclic Adenosine Monophosphate SignalingSerum Concentration-effect RelationshipsSignal Transduction By Cyclic Nucleotides
Intracellular concentrations of cyclic AMP increase when cells are deprived of serum. Studies with the mouse fibroblast line 3T3, an SV40-transformed subline of 3T3, and six different revertant lines derived from this clone show that a marked increase in cyclic AMP occurs only when the serum concentration is reduced below the minimum necessary for growth of a given line. Conversely, density-dependent inhibition of growth is not accompanied by an increase in cyclic AMP concentration in any line.
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Anchorage and growth regulation in normal and virus‐transformed cells
M. G. P. Stoker, C.H. O'Neill, S. Berryman et al. · International Journal of Cancer · 1968 · 548 citations