Diastereo- and Enantioselective Pd(II)-Catalyzed Additions of 2-Alkylazaarenes to <i>N</i>-Boc Imines and Nitroalkenes

Abstract

A chiral Pd(II)-bis(oxazoline) complex was found to be highly effective in promoting the first direct diastereo- and enantioselective addition of alkylazaarenes to N-Boc aldimines and nitroalkenes under mild conditions. Deprotection of Boc-protected products proceeded readily to provide amines in high yields.