Novel approach for the synthesis of Fe₃O₄@TiO₂core–shell microspheres and their application to the highly specific capture of phosphopeptides for MALDI-TOF MS analysis

Abstract

A novel approach is proposed to synthesize Fe(3)O(4)@TiO(2) microspheres with a well-defined core-shell structure, and the synthesized Fe(3)O(4)@TiO(2) core-shell microspheres were successfully applied for the simple and fast enrichment of phosphopeptides via direct MALDI-TOF mass spectrometry analysis.