Concepedia

Application of PBPK modeling to predict monoclonal antibody disposition in plasma and tissues in mouse models of human colorectal cancer

Lubna Abuqayyas, Joseph P. Balthasar

Journal of Pharmacokinetics and Pharmacodynamics · 2012 · 51 citations · 38 references

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References

38

Transport of molecules in the tumor interstitium: a review.

PubMed · 1987 · 1.4K citations

, , +17

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.

PubMed · 1990 · 578 citations

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Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Dhaval K. Shah, Alison Betts · Journal of Pharmacokinetics and Pharmacodynamics · 2011 · 417 citations

, , +10

Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.

Malik E. Juweid, Ronald D. Neumann, Chang H. Paik et al. · PubMed · 1992 · 405 citations

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A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier.

Kenji Fujimori, David G. Covell, John Fletcher et al. · PubMed · 1990 · 359 citations

, , +16