Deuterium exchange of C-methyl protons in 6,7-dimethyl-8-D-ribityl-lumazine, and studies of the mechanism of riboflavin biosynthesis

Abstract

The 7-methyl protons of 6,7-dimethyl-8-D-ribityl-lumazine and some analogues exchange with deuterium, and the deuteriated 8-hydroxyethyl-6,7-dimethyl-lumazine has been converted into a deuteriated flavin in a reaction which simulates the biosynthesis of riboflavin.