CORTISONE-THYROID THERAPY OF METASTATIC MAMMARY CANCER

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Article1 March 1957CORTISONE-THYROID THERAPY OF METASTATIC MAMMARY CANCERH. M. LEMON, M.D., F.A.C.P.H. M. LEMON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-3-457 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONRecent studies by the New York State Department of Health indicate that, in that area, mammary cancer is the most frequently reported of all human tumors and is the most important single cause of death from cancer.1As a result of the magnitude of this public health problem and the well known rôle of sex hormones in mammary development, there has been much interest recently in hormonal treatment of inoperable mammary cancer. It has been shown that various androgens and estrogens frequently induce subjective and objective remission of the disease,2and that oophorectomy,3total adrenalectomy4and total hypophysectomy5may...Bibliography1. Gerhardt PR, Director, 1954 Annual Report. Google Scholar2. AubNathanson JCIT: Neoplastic diseases, Ann. Rev. Med. 2: 343-366, 1951. CrossrefMedlineGoogle Scholar3. AdairTrevesFarrowScharnagel FENJHIM: Clinical effects of surgical and x-ray castration in mammary cancer, J. A. M. A. 128: 161-167, 1945. CrossrefGoogle Scholar4. HugginsDao CTL: Adrenalectomy for mammary cancer. Surgical technic of bilateral one-stage adrenalectomy in man, Ann. Surg. 136: 595-603, 1952. MedlineGoogle Scholar5. LuftOlivecrona RH: Hypophysectomy in man. Experiences in metastatic cancer of the breast, Cancer 8: 261-270, 1955. CrossrefMedlineGoogle Scholar6. Nathanson IT: Clinical investigative experience with steroid hormones in breast cancer, Cancer 5: 754-762, 1952. CrossrefMedlineGoogle Scholar7. 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DiczfaluseyLuft ER: Qualitative study on estrogens excreted by male patient with adrenal cortical tumor, Acta endocrinol. 9: 327-332, 1952. CrossrefMedlineGoogle Scholar54. Cabot Case Record No. 41121, Massachusetts General Hospital, New England J. Med. 252: 496-499, 1955. CrossrefMedlineGoogle Scholar55. LemonWotiz HMHH: Unpublished observations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H. M. LEMON, M.D., F.A.C.P.Affiliations: Boston, Massachusetts*Received for publication June 11, 1956. (Presented in part, April 15, 1955, at the Annual Meeting of the American Association for Cancer Research, San Francisco, California.)From the Robert Dawson Evans Memorial, Massachusetts Memorial Hospitals, and the Department of Medicine, Boston University School of Medicine. These studies have been assisted by teaching and research grants from the United States Public Health Service and an Institutional Grant from the American Cancer Society. Merck, Inc. generously provided part of the steroids utilized.Requests for reprints should be addressed to H. M. Lemon, M.D., 80 E. Concord St., Boston 18, Massachusetts. 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