Regioselective<i>O</i>-<i>p</i>-Toluenesulfonylation of Nucleosides Under Solid/Liquid Phase-Transfer Conditions

Abstract

The regioselective mono-O-p-toluenesulfonylation of nucleosides under phase-transfer conditions in which dibutyltin oxide acts as a base is reported. The selectivity is dependent upon both the solvent and ammonium quaternary salt.