Enantioselective Synthesis of SSR 241586 by Using an Organo-Catalyzed Henry Reaction

Abstract

An organo-catalyzed Henry reaction, applied to an alpha-keto ester, has allowed the enantioselective synthesis of SSR 241586, a 2,2-disubstituted morpholine active in the treatment of schizophrenia and irritable bowel syndrome (IBS).