Single‐Molecule Determination of the Face‐Specific Adsorption of Amelogenin’s C‐Terminus on Hydroxyapatite

Abstract

On the face of it: An atomic force microscopy tip, functionalized with Amelogenin protein (Amel), is used to directly determine the single-molecule, face-specific free energy of Amel binding to crystalline hydroxyapatite (see picture). The experimental values compare well with those from molecular dynamics simulations and enable the key interactions controlling face-specific binding to be identified. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.