Synthesis of the Mannopeptimycin Disaccharide and Its Conjugation with 4‐Alkylidene‐β‐lactams

Abstract

Abstract The disaccharide moiety of the antibiotic mannopeptimycin has been synthesized as a ( N ‐phenyl)trifluoroacetimidate donor, the reactivity of which was tested in conjugation with a 4‐alkylidene‐β‐lactam acceptor. Key steps of the synthesis were Bi(OTf) 3 ‐catalyzed glycosidations that proceeded in short times and with high yields and stereocontrol. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)